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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9260375 B1

PDFFull Text
Date of Patent:
Feb. 16, 2016

Filed:

Nov. 29, 2011

Metallo-β-lactamase inhibitors

Applicants:

Ken Chikauchi, Kawasaki, JP;

Mizuyo Ida, Yokohama, JP;

Takao Abe, Sakado, JP;

Yukiko Hiraiwa, Sagamihara, JP;

Akihiro Morinaka, Kawasaki, JP;

Toshiaki Kudo, Yokohama, JP;

Inventors:

Ken Chikauchi, Kawasaki, JP;

Mizuyo Ida, Yokohama, JP;

Takao Abe, Sakado, JP;

Yukiko Hiraiwa, Sagamihara, JP;

Akihiro Morinaka, Kawasaki, JP;

Toshiaki Kudo, Yokohama, JP;

Assignee:

Meiji Seika Kaisha, Ltd., Tokyo-To, JP;

Attorney:

Wenderoth, Lind & Ponack, L.L.P.

Primary Examiner:

Shengjun Wang

Int. Cl.
CPC ...
C07C 57/02 (2006.01); A61K 31/43 (2006.01); A61K 31/397 (2006.01); A61K 31/00 (2006.01); C07C 69/593 (2006.01); A61K 31/194 (2006.01); C07C 57/145 (2006.01); A61K 31/445 (2006.01); A61K 31/495 (2006.01); A61K 31/5375 (2006.01); A61K 45/06 (2006.01); C07C 51/00 (2006.01); C07C 57/13 (2006.01); C07C 57/26 (2006.01); C07C 57/42 (2006.01); C07C 57/50 (2006.01); C07C 59/52 (2006.01); C07C 59/64 (2006.01); C07C 59/70 (2006.01); C07C 69/618 (2006.01); C07C 69/734 (2006.01); C07C 217/22 (2006.01); C07C 233/65 (2006.01); C07C 235/20 (2006.01); C07C 237/22 (2006.01); C07C 279/08 (2006.01); C07C 323/54 (2006.01); C07D 211/46 (2006.01); C07D 211/60 (2006.01); C07D 213/80 (2006.01); C07D 295/192 (2006.01); C07D 309/06 (2006.01); A61K 31/407 (2006.01); A61K 31/546 (2006.01);
U.S. Cl.
CPC ...
C07C 69/593 (2013.01); A61K 31/194 (2013.01); A61K 31/445 (2013.01); A61K 31/495 (2013.01); A61K 31/5375 (2013.01); A61K 45/06 (2013.01); C07C 51/00 (2013.01); C07C 57/13 (2013.01); C07C 57/145 (2013.01); C07C 57/26 (2013.01); C07C 57/42 (2013.01); C07C 57/50 (2013.01); C07C 59/52 (2013.01); C07C 59/64 (2013.01); C07C 59/70 (2013.01); C07C 69/618 (2013.01); C07C 69/734 (2013.01); C07C 217/22 (2013.01); C07C 233/65 (2013.01); C07C 235/20 (2013.01); C07C 237/22 (2013.01); C07C 279/08 (2013.01); C07C 323/54 (2013.01); C07D 211/46 (2013.01); C07D 211/60 (2013.01); C07D 213/80 (2013.01); C07D 295/192 (2013.01); C07D 309/06 (2013.01); A61K 31/407 (2013.01); A61K 31/546 (2013.01); C07C 2101/08 (2013.01); C07C 2101/14 (2013.01); C07C 2102/08 (2013.01);
Abstract

A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

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