The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2016
Filed:
Aug. 31, 2005
Geoffrey Gerard Hayes, Saffron Walden, GB;
Vincenzo Martinelli, Cambridge, GB;
Hassan Mohammad, Ely, GB;
Harjit Tamber, Hitchin, GB;
Malcolm Walden, Hardwick, GB;
Steve Whitelock, Milton, GB;
Geoffrey Gerard Hayes, Saffron Walden, GB;
Vincenzo Martinelli, Cambridge, GB;
Hassan Mohammad, Ely, GB;
Harjit Tamber, Hitchin, GB;
Malcolm Walden, Hardwick, GB;
Steve Whitelock, Milton, GB;
EURO-CELTIQUE S.A., Luxembourg, LU;
Abstract
Extrusion of a mix containing a pharmaceutically active agent can be achieved using a plasticizing excipient in an amount sufficient to act as plasticizer and also act as lubricant, thereby avoiding the need for inclusion of a lubricant. The invention provides multiparticulates with controlled release properties, substantially free of lubricant. The present invention is preferably directed to extruded multiparticulates containing an opioid such as oxycodone, an ammonium methacrylate copolymer such as Eudragit® RSPO, a plasticizing excipient such as preferably stearyl alcohol and a water permeability modifier such as preferably Eudragit® RLPO. The obtained multiparticulates show a release rate profile which is pH-independent.