The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 16, 2016

Filed:

Dec. 23, 2013
Applicant:

Los Angeles Biomedical Research Institute AT Harbor-ucla Medical Center, Torrance, CA (US);

Inventors:

Ashraf S. Ibrahim, Irvine, CA (US);

Mingfu Liu, Carson, CA (US);

Brad Spellberg, Rancho Palos Verdes, CA (US);

Scott Filler, Rancho Palos Verdes, CA (US);

Yue Fu, Torrance, CA (US);

John E. Edwards, Palos Verdes Estates, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 39/00 (2006.01); A61K 31/713 (2006.01); C07K 16/14 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 39/39575 (2013.01); A61K 31/713 (2013.01); A61K 39/0002 (2013.01); A61K 39/0005 (2013.01); C07K 16/14 (2013.01); C12N 15/1138 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2799/027 (2013.01); C12N 2799/06 (2013.01);
Abstract

The present invention provides therapeutic compositions and methods for treating and preventing fungal disease or conditions including mucormycosis. The therapeutic methods and compositions of the invention include antibody, antibody fragment, siRNA and vaccine compositions having or directed against a GRP78 polypeptide or an antigenic fragment of the polypeptide.


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