The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2016
Filed:
Jan. 06, 2015
Applicant:
Celgene Corporation, Summit, NJ (US);
Inventors:
William McCulloch, Raleigh, NC (US);
Richard L. Piekarz, Silver Spring, MD (US);
Susan E. Bates, Bethesda, MD (US);
Assignees:
Gelgene Corporation, Summit, NJ (US);
The United States of America Department of Health and Human Services, Washington, DC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/15 (2006.01); A61K 33/00 (2006.01); A61K 33/06 (2006.01); A61P 35/00 (2006.01); A61K 31/19 (2006.01); A61K 33/14 (2006.01);
U.S. Cl.
CPC ...
A61K 38/15 (2013.01); A61K 31/19 (2013.01); A61K 33/00 (2013.01); A61K 33/06 (2013.01); A61K 33/14 (2013.01);
Abstract
The present invention relates to deacetylase inhibitor (e.g., histone deacetylase inhibitor) therapies and demonstrates that individuals with low electrolyte levels may have increased susceptibility to certain unwanted side effects such as cardiac side effects. In some embodiments, the invention provides methods of administering DAC or DAC inhibitor therapy that includes electrolyte supplementation.