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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9259434 B1

PDFFull Text
Date of Patent:
Feb. 16, 2016

Filed:

Jul. 16, 2013

Biopolymer system for tissue sealing

Applicant:

Endomedix, Inc., Newark, NJ (US);

Inventors:

Weiliam Chen, Mount Sinai, NY (US);

John M. Abrahams, Scarsdale, NY (US);

Assignee:

Endomedix, Inc., Newark, NJ (US);

Attorney:

Goodwin Procter LLP

Primary Examiner:

Michael G Hartley

Assistant Examiner:

Jagadishwar Samala

Int. Cl.
CPC ...
A61K 31/722 (2006.01); A61K 9/00 (2006.01); A61K 38/18 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61K 49/00 (2006.01); A61K 49/04 (2006.01); A61K 51/12 (2006.01); A61L 24/00 (2006.01); A61L 24/04 (2006.01); A61L 24/08 (2006.01); A61L 24/10 (2006.01); A61K 31/721 (2006.01); A61K 9/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/722 (2013.01); A61K 31/721 (2013.01); A61K 38/1875 (2013.01); A61K 47/48215 (2013.01); A61K 47/48784 (2013.01); A61K 48/00 (2013.01); A61K 49/0002 (2013.01); A61K 49/0457 (2013.01); A61K 51/1213 (2013.01); A61L 24/0031 (2013.01); A61L 24/043 (2013.01); A61L 24/08 (2013.01); A61L 24/104 (2013.01); A61K 9/0085 (2013.01); A61K 9/06 (2013.01);
Abstract

A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.

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