logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9259402 B1

PDFFull Text
Date of Patent:
Feb. 16, 2016

Filed:

Feb. 15, 2015

Compounds with (1 e, 6e)-1,7-bis-(3,4-dimethoxyphenyi)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof

Applicant:

Androscience Corporation, Solana Beach, CA (US);

Inventors:

Charles Shih, Solana Beach, CA (US);

Qian Shi, Chapel Hill, NC (US);

Hui-Kang Wang, San Diego, CA (US);

Assignee:

Allianz Pharmascience Ltd., Taipei, TW;

Attorney:

Cesari and McKenna LLP

Primary Examiner:

Sikarl Witherspoon

Int. Cl.
CPC ...
A61K 31/12 (2006.01); C07D 295/192 (2006.01); C07C 309/65 (2006.01); C07D 277/46 (2006.01); C07C 69/618 (2006.01); C07C 235/78 (2006.01); C07C 49/255 (2006.01); A61K 31/165 (2006.01); A61K 31/426 (2006.01); A61K 31/5375 (2006.01); A61K 31/255 (2006.01);
U.S. Cl.
CPC ...
A61K 31/12 (2013.01); A61K 31/165 (2013.01); A61K 31/255 (2013.01); A61K 31/426 (2013.01); A61K 31/5375 (2013.01); C07C 49/255 (2013.01); C07C 69/618 (2013.01); C07C 235/78 (2013.01); C07C 309/65 (2013.01); C07D 277/46 (2013.01); C07D 295/192 (2013.01); Y10S 514/884 (2013.01);
Abstract

The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.

Find Patent Forward Citations

Loading…