The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2016
Filed:
Mar. 08, 2010
Winfried Siffert, Gelsenkirchen, DE;
Kathrin Riemann, Essen, DE;
Winfried Siffert, Gelsenkirchen, DE;
Kathrin Riemann, Essen, DE;
Universitaet Duisburg-Essen, Essen, DE;
Abstract
The invention relates to the use of gene modifications in the human gene CHK2 (CHEK2), which encodes the checkpoint kinase 2, for predicting the risk and progression of cancer diseases, for predicting the response to pharmacological or non-pharmacological therapeutic measures for treating cancer diseases, and for predicting undesired effects of drugs. The invention further relates to the provision of individual gene variants with the help of which further gene modifications that can be used for the aforementioned purposes can be detected and validated. Such gene modifications can comprise a substitution of adenine for guanine in position −7161 in the promoter of CHK2, a substitution of guanine for cytosine in position −7235, a substitution of adenine for guanine in position −10532, or a deletion of 29 base pairs in positions −10621 to −10649.