The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 09, 2016

Filed:

Feb. 10, 2014
Applicants:

Kyoto University, Kyoto, JP;

Nepa Gene Co., Ltd., Chiba, JP;

Inventors:

Hideya Fukuzawa, Kyoto, JP;

Takashi Yamano, Kyoto, JP;

Kentaro Ifuku, Kyoto, JP;

Yasuhiko Hayakawa, Chiba, JP;

Assignees:

Kyoto University, Kyoto, JP;

Nepa Gene Co., Ltd., Chiba, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/87 (2006.01); C12N 15/74 (2006.01); C12N 15/82 (2006.01); A61N 1/04 (2006.01);
U.S. Cl.
CPC ...
C12N 15/8206 (2013.01); A61N 1/0412 (2013.01);
Abstract

A method of transferring an exogenous gene into a eukaryotic algal cell, the method including performing electroporation using multiple square-wave pulses to the solution containing a cell of a green alga with cell-wall, and a nucleic acid molecule by the following three steps: applying a square-wave electric pulse (first electric pulse) with a high voltage for a short period of time under the condition that its total electric energy falls within a predetermined range; then applying a square-wave electric pulse (second electric pulse) with a low voltage for a long period of time two or more times; and then applying a square-wave electric pulse (third electric pulse) that is opposite in polarity to the second electric pulse, with a low voltage for a long period of time, two or more times.


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