The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2016
Filed:
Aug. 06, 2010
Özlem Türeci, Mainz, DE;
Ugur Sahin, Mainz, DE;
Sandra Schneider, Stutensee, DE;
Gerd Helftenbein, Germünden, DE;
Volker Schlüter, Neuried, DE;
Dirk Usener, Wiesbaden, DE;
Philippe Thiel, Planegg, DE;
Michael Koslowski, Mainz, DE;
Özlem Türeci, Mainz, DE;
Ugur Sahin, Mainz, DE;
Sandra Schneider, Stutensee, DE;
Gerd Helftenbein, Germünden, DE;
Volker Schlüter, Neuried, DE;
Dirk Usener, Wiesbaden, DE;
Philippe Thiel, Planegg, DE;
Michael Koslowski, Mainz, DE;
GANYMED PHARMACEUTICALS AG, Mainz, DE;
Abstract
An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.