The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 02, 2016

Filed:

Oct. 15, 2012
Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Jingyue Ju, Englewood Cliffs, NJ (US);

Donald W. Landry, New York, NY (US);

Qiao Lin, New York, NY (US);

ThaiHuu Nguyen, Richmond, VA (US);

Renjun Pei, Jiangsu, CN;

Chunmei Oiu, New York, NY (US);

Milan N. Stojanovic, Fort Lee, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); G01N 1/40 (2006.01); G01N 21/64 (2006.01);
U.S. Cl.
CPC ...
G01N 1/4055 (2013.01); C12Q 1/6816 (2013.01); G01N 21/6408 (2013.01); Y10T 436/143333 (2015.01); Y10T 436/24 (2015.01); Y10T 436/25375 (2015.01);
Abstract

The described subject matter includes techniques and components for minimally invasive, selective capture and release of analytes. An aptamer is selected for its binding affinity with a particular analyte(s). The aptamer is functionalized on a solid phase, for example, microbeads, polymer monolith, microfabricated solid phase, etc. The analyte is allowed to bind to the aptamer, for example, in a microchamber. Once the analyte has been bound, a temperature control sets the temperature to an appropriate temperature at which the captured analyte is released.


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