The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 02, 2016

Filed:

Dec. 11, 2013
Applicants:

Regents of the University of Minnesota, Minneapolis, MN (US);

Healthpartners Research & Education, Bloomington, MN (US);

Inventors:

Daniel A. Wolf, Cambridge, MA (US);

William H. Frey, II, White Bear Lake, MN (US);

R. Scott McIvor, St. Louis Park, MN (US);

Leah R. Hanson, Vadnais Heights, MN (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 38/46 (2006.01); A61K 38/47 (2006.01); C12N 9/24 (2006.01); C12N 9/18 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 9/0043 (2013.01); A61K 38/46 (2013.01); A61K 38/465 (2013.01); A61K 38/47 (2013.01); C12N 9/18 (2013.01); C12N 9/2402 (2013.01); C12Y 301/06013 (2013.01); C12Y 302/0105 (2013.01); C12Y 302/01022 (2013.01); C12Y 302/01023 (2013.01); C12Y 302/01031 (2013.01); C12Y 302/01045 (2013.01); C12Y 302/01052 (2013.01); C12Y 302/01076 (2013.01);
Abstract

The invention provides a method to prevent, inhibit or treat one or more neurological symptoms associated with a lysosomal storage disease in a mammal in need thereof, which includes intranasally administering to the mammal a composition comprising an effective amount of a lysosomal storage enzyme or a recombinant adeno-associated virus vector comprising an open reading frame encoding a lysosomal storage enzyme. Also provided are compositions and devices useful in the methods.


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