The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2016
Filed:
Mar. 24, 2014
Applicant:
Novartis Vaccines and Diagnostics Srl, Siena, IT;
Inventors:
Maria Arico, Siena, IT;
Maurizio Comanducci, Siena, IT;
Assignee:
GlaxoSmithKline Biologicals SA, Rixensart, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/22 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/22 (2013.01); A61K 39/00 (2013.01); A61K 2039/53 (2013.01);
Abstract
NadA, App and ORF40 function as adhesins in. Adhesion nad be modulated by targeting these three proteins. NadA allelic variants are also disclosed. Autoproteolytic cleavage of App is disclosed, as is removal of the activity by mutagenesis. App is processed and secreted into culture medium when expressed in. Mature App proteins are disclosed. Knockout mutants are disclosed. Vesicles from non-Neisserial hosts with heterologous adhesion expression are disclosed.