The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2016
Filed:
Oct. 01, 2010
Applicants:
Ming-ming Zhou, Old Greenwich, CT (US);
Shiraz Mujtaba, New York, NY (US);
Inventors:
Ming-ming Zhou, Old Greenwich, CT (US);
Shiraz Mujtaba, New York, NY (US);
Assignee:
MOUNT SINAI SCHOOL OF MEDICINE, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 14/005 (2006.01); C12N 9/10 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); C12N 9/1007 (2013.01); A61K 48/00 (2013.01); C07K 2319/09 (2013.01); C12N 2710/00022 (2013.01); C12N 2710/10343 (2013.01); C12N 2740/15043 (2013.01);
Abstract
The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a viral SET domain histone lysine methyltransferase (vSET or vSET-like protein) methylates lysine 27 of a gene's histone protein 3 (H3-K27) thereby suppressing the transcription of the gene.