The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2016
Filed:
Dec. 15, 2011
Philipp Hadwiger, Kulmbach, DE;
Torsten Hoffmann, Weil am Rhein, DE;
Eric A. Kitas, Aesch BL, CH;
Peter Mohr, Basel, CH;
Ingo Roehl, Memmelsdorf, DE;
Linda Valis, Bamberg, DE;
David B. Rozema, Middleton, WI (US);
David L. Lewis, Madison, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
Philipp Hadwiger, Kulmbach, DE;
Torsten Hoffmann, Weil am Rhein, DE;
Eric A. Kitas, Aesch BL, CH;
Peter Mohr, Basel, CH;
Ingo Roehl, Memmelsdorf, DE;
Linda Valis, Bamberg, DE;
David B. Rozema, Middleton, WI (US);
David L. Lewis, Madison, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
Arrowhead Madison Inc., Madison, WI (US);
Abstract
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.