The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2016
Filed:
Oct. 01, 2013
Opko Health, Inc., Miami, FL (US);
George G. Wu, Basking Ridge, NJ (US);
Gerald Werne, Ketsch, DE;
Xiaoyong Fu, Edison, NJ (US);
Robert K. Orr, Cranford, NJ (US);
Frank Xing Chen, Plainsboro, NJ (US);
Jian Cui, Edison, NJ (US);
Victoria M. Sprague, Bridgewater, NJ (US);
Fucheng Zhang, Edison, NJ (US);
Ji Xie, Edison, NJ (US);
Liansheng Zeng, Union, NJ (US);
Louis Peter Castellanos, Union City, NJ (US);
Yuyin Chen, Garwood, NJ (US);
Marc Poirier, Stewartsville, NJ (US);
Ingrid Mergelsberg, Mahwah, NJ (US);
OPKO Health, Inc., Miami, FL (US);
Abstract
This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.