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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9249101 B1

PDFFull Text
Date of Patent:
Feb. 02, 2016

Filed:

Oct. 28, 2011

Tau imaging probe

Applicants:

Yukitsuka Kudo, Sendai, JP;

Shozo Furumoto, Sendai, JP;

Nobuyuki Okamura, Sendai, JP;

Inventors:

Yukitsuka Kudo, Sendai, JP;

Shozo Furumoto, Sendai, JP;

Nobuyuki Okamura, Sendai, JP;

Assignee:

CLINO LTD., Sendai-shi Miyagi, JP;

Attorneys:

Nixon Peabody LLP

Jeffrey L. Costellia

Primary Examiner:

Wu-Cheng Winston Shen

Assistant Examiner:

Jean Cornet

Int. Cl.
CPC ...
A61K 31/535 (2006.01); C07D 215/12 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 51/04 (2006.01); C07D 215/20 (2006.01); C07D 215/233 (2006.01); C07D 215/26 (2006.01); C07D 215/38 (2006.01); C07D 215/40 (2006.01); C07D 401/04 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 498/04 (2006.01); C07D 215/14 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07D 215/12 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 51/0455 (2013.01); A61K 51/0463 (2013.01); C07D 215/14 (2013.01); C07D 215/20 (2013.01); C07D 215/233 (2013.01); C07D 215/26 (2013.01); C07D 215/38 (2013.01); C07D 215/40 (2013.01); C07D 401/04 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 498/04 (2013.01); G01N 33/6893 (2013.01);
Abstract

An object of the present invention is to provide a probe for imaging a β-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R, R, R, R, R, R, Rand Rare as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.

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