The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 02, 2016

Filed:

Sep. 07, 2012
Applicants:

John Feutrill, Rosanna, AU;

Caroline Leriche, Paris, FL (US);

David Middlemiss, Bishop's Storford Hertfordshire, GB;

Inventors:

John Feutrill, Rosanna, AU;

Caroline Leriche, Paris, FL (US);

David Middlemiss, Bishop's Storford Hertfordshire, GB;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 217/84 (2006.01); C07C 235/56 (2006.01); C07C 233/75 (2006.01); C07C 255/59 (2006.01); C07C 63/72 (2006.01); C07C 13/02 (2006.01); C07C 13/08 (2006.01); C07C 235/20 (2006.01); C07C 237/30 (2006.01); A61K 31/196 (2006.01); A61K 45/06 (2006.01); A61K 31/216 (2006.01); C07C 215/76 (2006.01); C07C 65/105 (2006.01); C07C 65/24 (2006.01); A61K 31/165 (2006.01); A61K 31/277 (2006.01); A61K 31/5375 (2006.01); C07C 213/02 (2006.01); C07C 213/08 (2006.01); C07C 253/30 (2006.01); C07C 255/57 (2006.01); C07C 255/58 (2006.01); C07D 295/088 (2006.01);
U.S. Cl.
CPC ...
C07C 217/84 (2013.01); A61K 31/165 (2013.01); A61K 31/196 (2013.01); A61K 31/216 (2013.01); A61K 31/277 (2013.01); A61K 31/5375 (2013.01); A61K 45/06 (2013.01); C07C 63/72 (2013.01); C07C 65/105 (2013.01); C07C 65/24 (2013.01); C07C 213/02 (2013.01); C07C 213/08 (2013.01); C07C 215/76 (2013.01); C07C 233/75 (2013.01); C07C 235/20 (2013.01); C07C 235/56 (2013.01); C07C 237/30 (2013.01); C07C 253/30 (2013.01); C07C 255/57 (2013.01); C07C 255/58 (2013.01); C07C 255/59 (2013.01); C07D 295/088 (2013.01);
Abstract

The present invention relates to aniline derivatives of formula (I), to their preparation and to their therapeutic application, for example in treating glaucoma: Formula (I), R1a represents H, an halogen, a (C-C)alkyl or a CN; R1b represents H, an halogen or a (C-C)alkyl; R1c represents H or a (C-C)alkyl; R2 represents H, an halogen, an OH, an O—(C-C)alkyl or (C-C)alkyl; R3 represents H, an halogen, a (C-C)alkyl, an OH, an O—(C-C)alkyl, a CONHor CN; R4 represents H, an halogen or a (C-C)alkyl; R5 represents H or F: R7 represents H or F; R8 represents H or F; R9 represents H or (C-C)alkyl, or one of its enantiomers.


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