The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 26, 2016

Filed:

Jun. 19, 2009
Applicants:

Karen Silence, Overijse, BE;

Mark Vaeck, Hofstade, BE;

Paul M. P. Van Bergen En Henegouwen, Utrecht, NL;

Inventors:

Karen Silence, Overijse, BE;

Mark Vaeck, Hofstade, BE;

Paul M. P. Van Bergen En Henegouwen, Utrecht, NL;

Assignee:

Ablynx N.V., Zwijnaarde, BE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); C07K 16/18 (2006.01); C07K 16/24 (2006.01); C07K 16/36 (2006.01); C07K 16/40 (2006.01); C07K 16/42 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2863 (2013.01); C07K 16/18 (2013.01); C07K 16/241 (2013.01); C07K 16/249 (2013.01); C07K 16/2875 (2013.01); C07K 16/36 (2013.01); C07K 16/40 (2013.01); C07K 16/4291 (2013.01); A61K 2039/505 (2013.01); C07K 2317/22 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2317/62 (2013.01); C07K 2317/626 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C07K 2319/00 (2013.01); C07K 2319/31 (2013.01);
Abstract

The invention relates to a method suitable for administering protein therapeutic molecules orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation so as to avoid inactivation, by using VHH polypeptides derived from Camelidae antibodies. The invention further relates to the said therapeutic molecules. The invention further relates to a method for delivering therapeutic molecules to the interior of cells. The invention further relates to polypeptide constructs including VHH directed against EGFR.


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