The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2016
Filed:
May. 22, 2014
Applicant:
Idera Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Ekambar R. Kandimalla, Southboro, MA (US);
Tao Lan, Arlington, MA (US);
Yukui Li, Newton, MA (US);
Dong Yu, Westboro, MA (US);
Daqing Wang, Bedford, MA (US);
Mallikarjuna Putta, Burlington, MA (US);
Sudhir Agrawal, Shrewsbury, MA (US);
Assignee:
Idera Pharamaceuticals, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07K 14/665 (2006.01); C12N 15/117 (2010.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 31/713 (2006.01);
U.S. Cl.
CPC ...
C07K 14/665 (2013.01); A61K 31/713 (2013.01); A61K 39/0005 (2013.01); A61K 39/395 (2013.01); A61K 39/3955 (2013.01); C12N 15/117 (2013.01); C12N 2310/17 (2013.01); C12N 2310/315 (2013.01); C12N 2310/318 (2013.01); C12N 2310/3183 (2013.01); C12N 2310/321 (2013.01); C12N 2310/33 (2013.01); C12N 2310/331 (2013.01); C12N 2310/336 (2013.01);
Abstract
The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.