The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2016
Filed:
Jan. 26, 2012
Applicants:
Ming Xian, Pullman, WA (US);
Jia Pan, Jupiter, FL (US);
Assignee:
Washington State University, Pullman, WA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 231/10 (2006.01); C07D 295/192 (2006.01); C07K 1/02 (2006.01); C07C 269/06 (2006.01); C07C 381/00 (2006.01); C07D 207/10 (2006.01); C07D 209/20 (2006.01); C07D 295/185 (2006.01);
U.S. Cl.
CPC ...
C07K 1/02 (2013.01); C07C 231/10 (2013.01); C07C 269/06 (2013.01); C07C 381/00 (2013.01); C07D 207/10 (2013.01); C07D 209/20 (2013.01); C07D 295/185 (2013.01); C07D 295/192 (2013.01);
Abstract
Provided are methods for forming a reactive S-nitroso thioacid (NTA), comprising nitrosation of a thioacid with a nitrosation reagent. Also provided are methods for: acylating a nucleophile including selective acylation with a high degree of selectivity toward amines over hydroxyls; amide or peptide bond formation; forming a dipeptide or polypeptide; and peptide coupling/ligation, comprising use of thioacid and amine starting materials, wherein the reactions are mediated by very reactive S-nitroso thioacid (NTA) intermediates enabling extremely fast reactions under mild conditions, providing for broad applications.