The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 26, 2016

Filed:

Jul. 20, 2012
Applicants:

Jacob W. Clary, Santa Cruz, CA (US);

Bakthan Singaram, Santa Cruz, CA (US);

Inventors:

Jacob W. Clary, Santa Cruz, CA (US);

Bakthan Singaram, Santa Cruz, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 5/04 (2006.01); C07F 5/02 (2006.01);
U.S. Cl.
CPC ...
C07F 5/04 (2013.01); C07F 5/025 (2013.01);
Abstract

Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be pre-formed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg. When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0° C. in about 1 hour to form a boronic acid compound.


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