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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9242970 B1

PDFFull Text
Date of Patent:
Jan. 26, 2016

Filed:

Nov. 09, 2011

Lactam derivatives useful as orexin receptor antagonists

Applicants:

Hamed Aissaoui, Pulversheim, FR;

Christoph Boss, Allschwil, CH;

Christine Brotschi, Allschwil, CH;

Bibia Heidmann, Altkirch, FR;

Thierry Sifferlen, Wentzwiller, FR;

Jodi T. Williams, Basel, CH;

Inventors:

Hamed Aissaoui, Pulversheim, FR;

Christoph Boss, Allschwil, CH;

Christine Brotschi, Allschwil, CH;

Bibia Heidmann, Altkirch, FR;

Thierry Sifferlen, Wentzwiller, FR;

Jodi T. Williams, Basel, CH;

Assignee:

ACTELION PHARMACEUTICALS LTD., Allschwil, CH;

Attorney:

Hoxie & Associates, LLC

Primary Examiner:

Yong Chong

Int. Cl.
CPC ...
A61K 31/365 (2006.01); C07D 413/10 (2006.01); C07D 207/26 (2006.01); C07D 207/273 (2006.01); C07D 211/76 (2006.01); C07D 215/08 (2006.01); C07D 215/14 (2006.01); C07D 223/10 (2006.01); C07D 241/06 (2006.01); C07D 401/06 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 405/06 (2006.01); C07D 405/14 (2006.01); C07D 407/04 (2006.01); C07D 409/06 (2006.01); C07D 413/06 (2006.01); C07D 417/06 (2006.01); C07D 417/10 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 413/10 (2013.01); A61K 31/365 (2013.01); C07D 207/26 (2013.01); C07D 207/273 (2013.01); C07D 211/76 (2013.01); C07D 215/08 (2013.01); C07D 215/14 (2013.01); C07D 223/10 (2013.01); C07D 241/06 (2013.01); C07D 401/06 (2013.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 405/06 (2013.01); C07D 405/14 (2013.01); C07D 407/04 (2013.01); C07D 409/06 (2013.01); C07D 413/06 (2013.01); C07D 417/06 (2013.01); C07D 417/10 (2013.01); C07D 417/14 (2013.01);
Abstract

The present invention relates to lactam derivatives of formula (I) wherein Y, R, Rand Rare as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

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