The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 26, 2016

Filed:

May. 18, 2012
Applicants:

Siegfried Benjamin Christensen, Iv, Collegeville, PA (US);

Rowena Christensen, King of Prussia, PA (US);

Donghui Qin, King of Prussia Pa, PA (US);

Hemant Joshi, King of Prussia, PA (US);

Raghuram S. Tangirala, King of Prussia, PA (US);

Inventors:

Siegfried Benjamin Christensen, IV, Collegeville, PA (US);

Donghui Qin, King of Prussia Pa, PA (US);

Hemant Joshi, King of Prussia, PA (US);

Raghuram S. Tangirala, King of Prussia, PA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 275/42 (2006.01); C07D 217/26 (2006.01); C07D 239/42 (2006.01); C07D 213/75 (2006.01); C07D 241/20 (2006.01); C07D 237/20 (2006.01); A61K 31/17 (2006.01); A61K 31/4418 (2006.01); A61K 31/444 (2006.01); A61K 31/472 (2006.01); A61K 31/4965 (2006.01);
U.S. Cl.
CPC ...
C07C 275/42 (2013.01); C07D 213/75 (2013.01); C07D 217/26 (2013.01); C07D 237/20 (2013.01); C07D 239/42 (2013.01); C07D 241/20 (2013.01);
Abstract

This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders.


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