The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2016
Filed:
Feb. 17, 2011
Dangshe MA, Millwood, NY (US);
William C. Olson, Yorktown Heights, NY (US);
Stephen Morris, Croton on Hudson, NY (US);
Robert J. Israel, Suffern, NY (US);
Dangshe Ma, Millwood, NY (US);
William C. Olson, Yorktown Heights, NY (US);
Stephen Morris, Croton on Hudson, NY (US);
Robert J. Israel, Suffern, NY (US);
PSMA Development Company, LLC, Tarrytown, NY (US);
Abstract
Methods of killing prostate-specific membrane antigen (PSMA)-expressing, taxane-resistant cancer cells are provided. In particular, PSMA-expressing, taxane-resistant cancer cells are contacted with an antibody-drug conjugate (ADC) that comprises an antibody or antigen-binding fragment thereof that specifically binds to PSMA conjugated to monomethylauristatin norephedrine or monomethylauristatin phenylalanine.