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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9241993 B1

PDFFull Text
Expired
Date of Patent:
Jan. 26, 2016

Filed:

Jan. 27, 2012

Inhibitors of branched-chain-aminotransferase-1 (bcat1) for the treatment of brain tumors

Applicants:

Bernhard Radlwimmer, Heidelberg, DE;

Martje Toenjes, Heidelberg, DE;

Sebastian Barbus, Heidelberg, DE;

Peter Lichter, Gaiberg, DE;

Inventors:

Bernhard Radlwimmer, Heidelberg, DE;

Martje Toenjes, Heidelberg, DE;

Sebastian Barbus, Heidelberg, DE;

Peter Lichter, Gaiberg, DE;

Assignee:

Deutsches Krebsforschungszentrum, Heidelberg, DE;

Attorney:

Crowell & Moring LLP

Primary Examiner:

Kimberly Chong

Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 39/395 (2006.01); A61K 31/00 (2006.01); A61K 31/7088 (2006.01); A61K 31/713 (2006.01); C12N 15/113 (2010.01); A61K 31/196 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39558 (2013.01); A61K 31/00 (2013.01); A61K 31/196 (2013.01); A61K 31/7088 (2013.01); A61K 31/713 (2013.01); C12N 15/113 (2013.01); C12N 15/1137 (2013.01); C12Y 206/01042 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01);
Abstract

Described is a compound capable of reducing or inhibiting (a) the biological activity of branched-chain-aminotranferase-1 (BCAT1) or (b) the expression of the gene encoding BCAT1 for use in a method of treating a neoplasia. A preferred compound is 1-(aminomethyl) cyclohexaneacetic acid (gabapentin).

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Radlwimmer, Bernhard. (2016). Inhibitors of branched-chain-aminotransferase-1 (bcat1) for the treatment of brain tumors (U.S. Patent No. 9241993). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9241993

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