The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2016
Filed:
Nov. 18, 2010
Christiane Otto, Berlin, DE;
Siegmund Wolf, Berlin, DE;
Christoph Freiberg, Wuppertal, DE;
Axel Harrenga, Wuppertal, DE;
Simone Greven, Dormagen, DE;
Mark Trautwein, Wülfrath, DE;
Sandra Bruder, Leverkusen, DE;
Andrea Eicker, Mönchengladbach, DE;
Andreas Wilmen, Köln, DE;
Christiane Otto, Berlin, DE;
Siegmund Wolf, Berlin, DE;
Christoph Freiberg, Wuppertal, DE;
Axel Harrenga, Wuppertal, DE;
Simone Greven, Dormagen, DE;
Mark Trautwein, Wülfrath, DE;
Sandra Bruder, Leverkusen, DE;
Andrea Eicker, Mönchengladbach, DE;
Andreas Wilmen, Köln, DE;
BAYER INTELLECTUAL PROPERTY GMBH, Monheim, DE;
Abstract
The present invention is directed to the neutralizing prolactin receptor antibody 005-C04, as well as maturated forms thereof, and antigen binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation. The antibodies of the invention block prolactin receptor-mediated signaling.