The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2016
Filed:
Apr. 30, 2012
Kathryn J. Moore, Westfield, NJ (US);
Katey J. Rayner, Ottowa, CA;
Frederick Sheedy, New York, NY (US);
Carlos Fernandez-hernando, New York, NY (US);
Yajaira Suarez, New York, NY (US);
Kathryn J. Moore, Westfield, NJ (US);
Katey J. Rayner, Ottowa, CA;
Frederick Sheedy, New York, NY (US);
Carlos Fernandez-Hernando, New York, NY (US);
Yajaira Suarez, New York, NY (US);
New York University, New York, NY (US);
Abstract
The inhibition of miRNA miR-33 is shown to promote the polarization of macrophages from an M1 to an M2 phenotype. MiR-33 inhibitors are therefore useful for treating inflammation in subjects. Endogenous microRNAs can be silenced using antagomirs. The miR-33 inhibitor is preferably an antagomir having a single-stranded nucleic acid sequence that is complementary to at least 12 contiguous nucleotides in miR-33 and therefore forms a duplex with miR-33 under physiological conditions.