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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9238654 B1

PDFFull Text
Date of Patent:
Jan. 19, 2016

Filed:

May. 09, 2013

Singleton inhibitors of sumoylation enzymes and methods for their use

Applicants:

City of Hope, Duarte, CA (US);

Sanford-burnham Medical Research Institute AT Lake Nona, Orlando, FL (US);

Inventors:

Yuan Chen, Arcadia, CA (US);

Yi-Jia Li, Duarte, CA (US);

Daniela Divlianska, Orlando, FL (US);

Ekaterina Bobkova, Orlando, FL (US);

Greg Roth, Orlando, FL (US);

Assignees:

City of Hope, Duarte, CA (US);

Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, FL (US);

Attorney:

Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.

Primary Examiner:

Raymond Henley, III

Int. Cl.
CPC ...
A61K 31/34 (2006.01); C07D 493/08 (2006.01); C07D 487/04 (2006.01); A61K 31/555 (2006.01); A61K 33/24 (2006.01); A61K 41/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/34 (2013.01); A61K 31/555 (2013.01); A61K 33/24 (2013.01); A61K 41/00 (2013.01); A61K 45/06 (2013.01); C07D 493/08 (2013.01);
Abstract

According to the embodiments described herein, a SUMOylation inhibitor compound comprising a singleton scaffold is provided. In some embodiments, a method for inhibiting a SUMOylation enzyme in a cell is provided. Such a method may include administering a SUMOylation inhibitor compound to the cell. In some aspects, the SUMOylation enzyme is SUMO E1 or SUMO E2. In some aspects, the method may be used to inhibit a cancer cell in vitro (e.g., grown in culture) or in vivo (e.g., as part of a tumor in a subject). In other embodiments, a method for treating a cancer, degenerative diseases and viral infection is provided. Such a method may include administering an effective amount of a pharmaceutical composition to a subject having the cancer. The pharmaceutical composition may include a singleton SUMOylation inhibitor compound. In some embodiments, the method for treating a cancer may further comprise administering one or more DNA-damaging therapy in combination with administration of the pharmaceutical composition.

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