The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 19, 2016

Filed:

Aug. 16, 2012
Applicants:

Feng Xu, Staten Island, NY (US);

Guy Humphrey, Hillsborough, NJ (US);

Tao Pei, Morganville, NJ (US);

Zhiguo Jake Song, Edison, NJ (US);

Tao Wang, Berkeley Heights, NJ (US);

Laura Artino, Oakhurst, NJ (US);

Inventors:

Feng Xu, Staten Island, NY (US);

Guy Humphrey, Hillsborough, NJ (US);

Tao Pei, Morganville, NJ (US);

Zhiguo Jake Song, Edison, NJ (US);

Tao Wang, Berkeley Heights, NJ (US);

Laura Artino, Oakhurst, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 5/08 (2006.01); C07K 5/10 (2006.01); C07K 5/12 (2006.01); C07D 401/12 (2006.01); C07C 35/04 (2006.01); C07K 5/083 (2006.01); C07D 403/12 (2006.01); C07D 498/16 (2006.01); C07C 67/14 (2006.01); C07C 69/013 (2006.01); C07C 69/12 (2006.01); C07C 269/04 (2006.01); C07C 271/34 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07C 35/04 (2013.01); C07C 67/14 (2013.01); C07C 69/013 (2013.01); C07C 69/12 (2013.01); C07C 269/04 (2013.01); C07C 271/34 (2013.01); C07D 403/12 (2013.01); C07D 498/16 (2013.01); C07K 5/0808 (2013.01); C07K 5/126 (2013.01); A61K 38/00 (2013.01);
Abstract

The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams from the intermediates. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.


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