The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 19, 2016
Filed:
Dec. 16, 2010
Thomas Joseph Sayers, Boonsboro, MD (US);
Nancy Lynn Booth, Bethesda, MD (US);
Curtis J. Henrich, Rockville, MD (US);
Alan David Brooks, Frederick, MD (US);
Kirk R. Gustafson, Frederick, MD (US);
Karen L. Erickson, North Oxford, MA (US);
Thomas Joseph Sayers, Boonsboro, MD (US);
Nancy Lynn Booth, Bethesda, MD (US);
Curtis J. Henrich, Rockville, MD (US);
Alan David Brooks, Frederick, MD (US);
Kirk R. Gustafson, Frederick, MD (US);
Karen L. Erickson, North Oxford, MA (US);
Abstract
Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with a death receptor ligand, which method comprises contacting the cancer cells with a death receptor ligand in conjunction with an effective amount of a compound described herein, for example, a cucurbitacin (I) or a withanolide (II). Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with a compound described herein, for example, a cucurbitacin (I) or a withanolide (II) and also contacting the cancer cells with a death receptor ligand, whereby apoptosis is induced in the cancer cells.