The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 19, 2016
Filed:
Jul. 09, 2014
Applicant:
The Translational Genomics Research Institute, Phoenix, AZ (US);
Inventors:
Nhan Tran, Phoenix, AZ (US);
Nathalie Meurice, Scottsdale, AZ (US);
Harshil Dhruv, Phoenix, AZ (US);
Assignee:
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, Phoenix, AZ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/47 (2006.01); A61K 31/542 (2006.01); A61K 31/53 (2006.01); A61K 45/06 (2006.01); A61K 31/541 (2006.01); A61K 31/4192 (2006.01); A61K 31/4188 (2006.01); A61K 31/4704 (2006.01); A61K 31/4745 (2006.01); A61K 33/24 (2006.01);
U.S. Cl.
CPC ...
A61K 31/542 (2013.01); A61K 31/4188 (2013.01); A61K 31/4192 (2013.01); A61K 31/4704 (2013.01); A61K 31/4745 (2013.01); A61K 31/53 (2013.01); A61K 31/541 (2013.01); A61K 33/24 (2013.01); A61K 45/06 (2013.01);
Abstract
The present disclosure is directed to methods of using fibroblast growth factor-inducible 14 (Fn14) antagonists to modulate activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of Fn14. The present disclosure also provides pharmaceutical compositions comprising synergistic combinations Fn14 antagonists and chemotherapeutic agents.