The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 19, 2016
Filed:
Jul. 18, 2014
Applicants:
Vib Vzw, Ghent, BE;
Life Sciences Research Partners Vzw, Leuven, BE;
Inventors:
Ludo Van Den Bosch, Arendonk, BE;
Constantin Van Outryve d'Ydewalle, Bruges, BE;
Wim Robberecht, Kumtich, BE;
Assignees:
VIB VZW, Gent, BE;
Life Sciences Research Partners VZW, Leuven, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/437 (2006.01); A61K 31/422 (2006.01); A01K 67/027 (2006.01);
U.S. Cl.
CPC ...
A61K 31/437 (2013.01); A01K 67/0275 (2013.01); A61K 31/422 (2013.01);
Abstract
The disclosure relates to diseases in the peripheral nervous system, particularly hereditary neuropathies, such as Charcot-Marie-Tooth (CMT) disease. It is shown that this disease is associated with decreased acetylated tubulin levels, which can be overcome by inhibition of histone deacetylases (HDACs). Using HDAC inhibitors, it is shown herein that the symptoms of the CMT phenotype can be overcome both in vitro and in vivo. Also provided herein are two different mouse models of CMT disease.