The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 2016
Filed:
Oct. 04, 2013
Applicant:
Consiglio Nazionale Delle Ricerche, Rome, IT;
Inventors:
Assignee:
CONSIGLIO NAZIONALE DELLE RICERCHE, Rome, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/115 (2010.01);
U.S. Cl.
CPC ...
C12N 15/115 (2013.01); C12N 2310/16 (2013.01); C12N 2310/3533 (2013.01);
Abstract
Nuclease-resistant RNA aptamers are provided which are capable of neutralizing PDGFRβ and are therefore useful in the diagnosis and/or therapy of PDGFRβ-associated and hyperproliferative-associated diseases, such as cancer and primary tumor metastasis. RNA aptamers provided herein include a modified synthetic RNA sequence wherein at least one pyrimidine residue is modified to 2'-fluoropyrimidine. Pharmaceutical compositions and diagnostic kits comprising RNA aptamers are also provided.