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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9234184 B1

PDFFull Text
Date of Patent:
Jan. 12, 2016

Filed:

Mar. 30, 2012

Nucleic acid construct comprising nucleic acid derived from genome of hepatitis c virus of genotype 1b, hepatitis c virus genome-replicating cells transfected with the same, and method for producing infectious hepatitis c virus particles

Applicants:

Takaji Wakita, Tokyo, JP;

Tomoko Date, Kanagawa, JP;

Yasuhito Tanaka, Aichi, JP;

Masashi Mizokami, Chiba, JP;

Inventors:

Takaji Wakita, Tokyo, JP;

Tomoko Date, Kanagawa, JP;

Yasuhito Tanaka, Aichi, JP;

Masashi Mizokami, Chiba, JP;

Assignees:

Japan as Represented by Director-General of National Institute of Infectious Diseases, Tokyo, JP;

Public University Corporation Nagoya City University, Nagoya-shi, JP;

Toray Industries, Inc., Tokyo, JP;

Attorney:

Birch, Stewart, Kolasch & Birch, LLP

Primary Examiner:

Shanon A Foley

Assistant Examiner:

Myron Hill

Int. Cl.
CPC ...
C12N 7/08 (2006.01); C12N 7/00 (2006.01); C12N 7/04 (2006.01); C12N 15/86 (2006.01); C07K 16/10 (2006.01); C12Q 1/70 (2006.01); C07K 16/08 (2006.01); C07K 14/005 (2006.01); A61K 39/12 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); A61K 39/12 (2013.01); C07K 14/005 (2013.01); C07K 16/082 (2013.01); C07K 16/109 (2013.01); C12N 15/86 (2013.01); C12Q 1/707 (2013.01); A61K 39/00 (2013.01); C12N 2770/24221 (2013.01); C12N 2770/24222 (2013.01); C12N 2770/24231 (2013.01); C12N 2770/24234 (2013.01); C12N 2770/24243 (2013.01); C12N 2770/24251 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/156 (2013.01);
Abstract

A subgenomic replicon RNA (nucleic acid) having an excellent autonomously replicating ability and a fullgenomic replicon RNA (nucleic acid) having an excellent autonomously replicating ability and infectious HCV particle-producing ability, each derived from a novel HCV of genotype 1b, are provided. Particularly, a subgenomic replicon RNA (nucleic acid) and a fullgenomic replicon RNA (nucleic acid), each derived from an HCV genome of the NC1 strain which is a novel HCV genotype 1b isolated from a patient with acute severe hepatitis C, are provided.

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