The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 2016
Filed:
Oct. 23, 2009
Applicants:
Alireza Rezania, Skillman, NJ (US);
Benjamin Fryer, Skillman, NJ (US);
Inventors:
Alireza Rezania, Skillman, NJ (US);
Benjamin Fryer, Skillman, NJ (US);
Assignee:
Janssen Biotech, Inc., Horsham, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0676 (2013.01); C12N 2501/115 (2013.01); C12N 2501/117 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/39 (2013.01); C12N 2501/405 (2013.01); C12N 2501/41 (2013.01); C12N 2501/70 (2013.01); C12N 2501/998 (2013.01); C12N 2506/02 (2013.01);
Abstract
The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependant kinase inhibitor to cause an increase in expression of MAFA.