The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 2016
Filed:
Dec. 08, 2011
Applicants:
Ki-bum Lee, Monmouth Junction, NJ (US);
Shreyas Shah, Dayton, NJ (US);
Inventors:
Ki-Bum Lee, Monmouth Junction, NJ (US);
Shreyas Shah, Dayton, NJ (US);
Assignee:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, New Brunswick, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12N 5/00 (2006.01); A61K 47/30 (2006.01); C12N 5/079 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0618 (2013.01); C12N 2506/45 (2013.01); C12N 2529/10 (2013.01); C12N 2533/30 (2013.01); C12N 2533/50 (2013.01); C12N 2535/10 (2013.01); C12N 2537/10 (2013.01);
Abstract
This application discloses a light-responsive hydrogel-based platform that can modulate multiple microenvironmental signals to direct the differentiation of human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) into neuronal cells. The invention provides novel methods for directing differentiation of neural stem cells into neurons useful for treatment of degenerative diseases or disorders, including but not limited to Alzheimer's, Parkinson's, or spinal cord injury (SCI).