The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 2016
Filed:
Jul. 02, 2010
Peter Carmeliet, Blanden, BE;
Frederik DE Smet, Leuven, BE;
Joost Schymkowitz, Meensel-Kiezegem, BE;
Frédéric Rousseau, Groot-Bijgaarden, BE;
Corentin Herbert, Paris, FR;
Peter Carmeliet, Blanden, BE;
Frederik De Smet, Leuven, BE;
Joost Schymkowitz, Meensel-Kiezegem, BE;
Frédéric Rousseau, Groot-Bijgaarden, BE;
Corentin Herbert, Paris, FR;
SANOFI, Paris, FR;
VIB VZW, Ghent, BE;
LIFE SCIENCES RESEARCH PARTNERS VZW, Leuven, BE;
VRIJE UNIVERSITEIT BRUSSEL, Brussels, BE;
Abstract
The present invention relates to an extracellular binding domain for an allosteric inhibitor, whereby said binding domain is derived from a single membrane span tyrosine kinase receptor. More specifically, the invention relates to an extracellular domain derived from a Fibroblast Growth Factor Receptor (FGFR). It further relates to the use of this domain for the identification of similar domains in the extracellular part of other tyrosine kinase receptors, and to a screening method for identification of a small compound allosteric inhibitor.