The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 12, 2016

Filed:

Sep. 26, 2013
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Kevin J. Wilson, Boston, MA (US);

David J. Witter, Norfolk, MA (US);

Phieng Siliphaivanh, Newton, MA (US);

Kathryn Lipford, Boston, MA (US);

David Sloman, Brookline, MA (US);

Danielle Falcone, Brookline, MA (US);

Brendan O'Boyle, Pittsburgh, PA (US);

Umar Faruk Mansoor, Framington, MA (US);

Jongwon Lim, Lexington, MA (US);

Joey L. Methot, Westwood, MA (US);

Christopher Boyce, Flemington, NJ (US);

Lei Chen, Basking Ridge, NJ (US);

Matthew H. Daniels, Somerville, MA (US);

Salem Fevrier, Cranford, NJ (US);

Xianhai Huang, Warren, NJ (US);

Ravi Kurukulasuriya, Niantic, CT (US);

Ling Tong, Warren, NJ (US);

Wei Zhou, Scotch Plains, NJ (US);

Joseph Kozlowski, Princeton, NJ (US);

Milana M. Maletic, Summit, NJ (US);

Bidhan A. Shinkre, Bangalore, IN;

Jayanth Thiruvellore Thatai, Bangalore, IN;

Raman Kumar Bakshi, Bangalore, IN;

Ganesh Babu Karunakaran, Bangalore, IN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); A61K 31/437 (2006.01); C07D 498/18 (2006.01); C07D 471/04 (2006.01); A61K 31/5377 (2006.01); A61K 31/496 (2006.01); C07D 471/14 (2006.01); A61K 31/4375 (2006.01); C07D 498/14 (2006.01); A61K 31/553 (2006.01); C07D 519/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 498/18 (2013.01); A61K 31/437 (2013.01); A61K 31/4375 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 31/553 (2013.01); A61K 45/06 (2013.01); C07D 471/04 (2013.01); C07D 471/14 (2013.01); C07D 498/14 (2013.01); C07D 519/00 (2013.01);
Abstract

Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1).


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