The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 2016
Filed:
Aug. 26, 2011
Applicants:
Kunyuan Cui, Bothell, WA (US);
Dong Liang, Everett, CN;
Inventors:
Kunyuan Cui, Bothell, WA (US);
Dong Liang, Everett, CN;
Assignee:
Other;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/22 (2006.01); C07D 257/02 (2006.01); C07D 255/02 (2006.01); C07D 259/00 (2006.01); A61K 47/48 (2006.01); C12N 15/87 (2006.01); C07D 295/13 (2006.01);
U.S. Cl.
CPC ...
C07D 487/22 (2013.01); A61K 47/481 (2013.01); A61K 47/48053 (2013.01); A61K 47/48092 (2013.01); C07D 255/02 (2013.01); C07D 257/02 (2013.01); C07D 259/00 (2013.01); C07D 295/13 (2013.01); C12N 15/87 (2013.01);
Abstract
What is described are macrocyclic compounds formed by reaction of a cyclic compound, which contains an amine, with an epoxide. The macrocyclic compound has the following structure: When substituents R and R' that are hydrophobic substituents, the macrocyclic compound functions as a lipid and is compatible with lipid systems, including liposomes and lipid particles. When present in certain lipid systems, the macrocyclic compound enhances the ability of the lipid system to facilitate delivery of therapeutic molecules to target cells in a mammalian subject.