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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9233941 B1

PDFFull Text
Date of Patent:
Jan. 12, 2016

Filed:

May. 05, 2014

Methods and compositions for the treatment of body weight related disorders

Applicants:

Motonari Uesugi, Osaka, JP;

Salih J. Wakil, Houston, TX (US);

Lutfi Abu-elheiga, Houston, TX (US);

Mizuki Watanabe, Kyoto, JP;

Inventors:

Motonari Uesugi, Osaka, JP;

Salih J. Wakil, Houston, TX (US);

Lutfi Abu-Elheiga, Houston, TX (US);

Mizuki Watanabe, Kyoto, JP;

Assignee:

Baylor College of Medicine, Houston, TX (US);

Attorney:

Benjamin A. Adler

Primary Examiner:

Yong Chu

Int. Cl.
CPC ...
A61K 31/427 (2006.01); A61K 31/4436 (2006.01); A61K 31/4439 (2006.01); C07D 277/66 (2006.01); C07D 417/04 (2006.01); A61K 45/06 (2006.01); A61K 31/428 (2006.01); C07D 471/04 (2006.01); A61K 31/437 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); A61K 31/4709 (2006.01); A61K 31/454 (2006.01); C07D 401/14 (2006.01); C07D 401/04 (2006.01); A61K 31/496 (2006.01); A23L 1/30 (2006.01); A23K 1/16 (2006.01); C07D 213/76 (2006.01); C07D 235/14 (2006.01); C07D 487/04 (2006.01); C07D 277/22 (2006.01); C07D 277/24 (2006.01); C07D 213/06 (2006.01); C07D 213/16 (2006.01); A61K 31/4418 (2006.01); A61K 31/495 (2006.01); A61K 31/5025 (2006.01);
U.S. Cl.
CPC ...
C07D 277/66 (2013.01); A23K 1/1628 (2013.01); A23L 1/30 (2013.01); A61K 31/427 (2013.01); A61K 31/428 (2013.01); A61K 31/437 (2013.01); A61K 31/4418 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/4709 (2013.01); A61K 31/495 (2013.01); A61K 31/496 (2013.01); A61K 31/5025 (2013.01); A61K 45/06 (2013.01); C07D 213/06 (2013.01); C07D 213/16 (2013.01); C07D 213/76 (2013.01); C07D 235/14 (2013.01); C07D 277/22 (2013.01); C07D 277/24 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention relates to methods for reducing body weight in an animal in need thereof via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B-C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently. Also provided are methods for increasing thermogenesis without reducing lean body mass during weight loss in an animal by administering of a therapeutically effective amount of the compounds described.

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