The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 12, 2016

Filed:

Feb. 02, 2015
Applicant:

The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);

Inventors:

Zhi-Ying Chen, Shenzhen, CN;

Mark A. Kay, Los Altos, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07K 14/195 (2006.01); C12N 15/70 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); A61K 48/005 (2013.01); C07K 14/195 (2013.01); C12N 15/70 (2013.01); C12N 15/85 (2013.01); C12N 2800/108 (2013.01); C12N 2800/24 (2013.01); C12N 2800/30 (2013.01); C12N 2800/80 (2013.01); C12N 2830/002 (2013.01); C12N 2830/55 (2013.01);
Abstract

The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest, a product hybrid sequence of a unidirectional site-specific recombinase, and are devoid of plasmid backbone bacterial DNA sequences. Also provided are methods of producing the subject formulations as well as methods for administering the minicircle nucleic acid vector formulations to a subject. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications.


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