The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 05, 2016

Filed:

Jun. 21, 2012
Applicants:

Brian Bettencourt, Groton, MA (US);

Akin Akinc, Needham, MA (US);

Alfica Sehgal, Allston, MA (US);

Don Foster, Attleboro, MA (US);

Stuart Milstein, Cambridge, MA (US);

Satyanarayana Kuchimanchi, Acton, MA (US);

Martin A. Maier, Belmont, MA (US);

Klaus Charisse, Acton, MA (US);

Kallanthottathil Rajeev, Wayland, MA (US);

Inventors:

Brian Bettencourt, Groton, MA (US);

Akin Akinc, Needham, MA (US);

Alfica Sehgal, Allston, MA (US);

Don Foster, Attleboro, MA (US);

Stuart Milstein, Cambridge, MA (US);

Satyanarayana Kuchimanchi, Acton, MA (US);

Martin A. Maier, Belmont, MA (US);

Klaus Charisse, Acton, MA (US);

Kallanthottathil Rajeev, Wayland, MA (US);

Assignee:

ALNYLAM PHARMACEUTICALS, INC., Cambridge, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 31/7105 (2006.01); A61K 33/26 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/7105 (2013.01); A61K 33/26 (2013.01); A61K 47/48092 (2013.01); C12N 15/1136 (2013.01); C12N 15/1138 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/3521 (2013.01); C12N 2310/3533 (2013.01); C12N 2320/30 (2013.01);
Abstract

The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) targeting a hepcidin antimicrobial peptide (HAMP) and/or HAMP-related gene, and methods of using the dsRNA to inhibit expression of HAMP and/or HAMP-related genes.


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