The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2016
Filed:
Feb. 04, 2011
Bira Arya, Baltimore, MD (US);
Purevdorj B. Olkhanud, Parkville, MD (US);
Monica Bodogai, Baltimore, MD (US);
Bira Arya, Baltimore, MD (US);
Purevdorj B. Olkhanud, Parkville, MD (US);
Monica Bodogai, Baltimore, MD (US);
Abstract
Regulatory B cells (tBreg) are disclosed herein. These regulatory B cells express CD25 (CD25) a pan B cell marker such as B220 (B220), and also express CD19 (CD19). These regulatory B cells suppress resting and activated T cells in cell contact-dependent manner. Methods for generating these regulatory B cells are also disclosed herein, as are methods for using these regulatory B cells to produce regulatory T cells (Treg). In some embodiments, methods for treating an immune-mediated disorder, such as an autoimmune disease, transplant rejection, graft-versus-host disease or inflammation, are disclosed. These methods include increasing regulatory B cell number or activity and/or by administering autologous regulatory B cells. Methods for treating cancer are also disclosed herein. These methods include decreasing regulatory B cell activity and/or number.