The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2016
Filed:
Mar. 10, 2011
Scott G. Kitchen, Los Angeles, CA (US);
Jerome A. Zack, Tarzana, CA (US);
Otto O. Yang, Los Angeles, CA (US);
Michael S. Bennett, Tucson, AZ (US);
Balamurugan Arumugam, Los Angeles, CA (US);
Scott G. Kitchen, Los Angeles, CA (US);
Jerome A. Zack, Tarzana, CA (US);
Otto O. Yang, Los Angeles, CA (US);
Michael S. Bennett, Tucson, AZ (US);
Balamurugan Arumugam, Los Angeles, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Disclosed herein are recombinant human progenitor cells, engineered human thymocytes, and engineered human T cells. The recombinant human progenitor cells are made by transducing a human hematopoietic stem cell with a vector having a nucleic acid molecule which encodes a human T cell receptor specific to a virus, such as Human Immunodeficiency Virus, or an epitope thereof. The recombinant human progenitor cells differentiate and mature into the engineered human thymocytes and the engineered human T cells. Also disclosed herein are methods of inhibiting, reducing or treating a viral infection in a subject, such as a human subject, which comprises administering recombinant human progenitor cells, engineered human thymocytes, and/or engineered human T cells to the subject.