The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 05, 2016

Filed:

Jan. 18, 2011
Applicants:

M. Arshad Siddiqui, Newton, MA (US);

Yang Nan, Malden, MA (US);

Mehul F. Patel, Blue Bell, PA (US);

Panduranga Adulla P. Reddy, Walpole, MA (US);

Umar Faruk Mansoor, Framingham, MA (US);

Zhaoyang Meng, Lansdale, PA (US);

Lalanthi Dilrukshi Vitharana, Somerville, MA (US);

Lianyun Zhao, Blue Bell, PA (US);

Amit K. Mandal, Shrewsbury, MA (US);

Duan Liu, Arlington, MA (US);

Shuyi Tang, Belmont, MA (US);

Andrew Mcriner, Melrose, MA (US);

David B. Belanger, Cambridge, MA (US);

Patrick J. Curran, Saugus, MA (US);

Chaoyang Dai, Acton, MA (US);

Angie R. Angeles, Boston, MA (US);

Liping Yang, Arlington, MA (US);

Matthew Hersh Daniels, Cambridge, MA (US);

Inventors:

M. Arshad Siddiqui, Newton, MA (US);

Yang Nan, Malden, MA (US);

Mehul F. Patel, Blue Bell, PA (US);

Panduranga Adulla P. Reddy, Walpole, MA (US);

Umar Faruk Mansoor, Framingham, MA (US);

Zhaoyang Meng, Lansdale, PA (US);

Lalanthi Dilrukshi Vitharana, Somerville, MA (US);

Lianyun Zhao, Blue Bell, PA (US);

Amit K. Mandal, Shrewsbury, MA (US);

Duan Liu, Arlington, MA (US);

Shuyi Tang, Belmont, MA (US);

Andrew McRiner, Melrose, MA (US);

David B. Belanger, Cambridge, MA (US);

Patrick J. Curran, Saugus, MA (US);

Chaoyang Dai, Acton, MA (US);

Angie R. Angeles, Boston, MA (US);

Liping Yang, Arlington, MA (US);

Matthew Hersh Daniels, Cambridge, MA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); C07D 471/08 (2006.01); C07D 498/08 (2006.01); C07D 491/147 (2006.01); C07D 487/08 (2006.01); C07D 513/08 (2006.01); C07D 519/00 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/08 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01); C07D 491/147 (2013.01); C07D 498/08 (2013.01); C07D 513/08 (2013.01);
Abstract

The present invention provides Pyrazolopyrimidine Compounds of Formula (I): wherein L, T, Z, U, V, W, R, R, R, R, and m are as defined herein, and pharmaceutically acceptable salts of such Pyrazolopyrimidine Compounds. The Pyrazolopyrimidine Compounds are useful in the treatment of cancer and other diseases or disorders wherein mTOR is deregulated.


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