The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2016
Filed:
Apr. 25, 2013
Applicant:
Eisai R&d Management Co., Ltd., Tokyo, JP;
Inventors:
Kazuhiro Yoshizawa, Kamisu, JP;
Masayuki Omori, Kamisu, JP;
Yuzo Watanabe, Kamisu, JP;
Mitsuo Nagai, Tsukuba, JP;
Masabumi Takahashi, Kamisu, JP;
Francis G. Fang, Andover, MA (US);
Assignee:
Eisai R&D Management Co., Ltd., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 241/24 (2006.01);
U.S. Cl.
CPC ...
C07D 241/24 (2013.01);
Abstract
5-(Difluoromethyl)pyrazine-2-carboxylic acid, which is a raw material for the construction of 5-(difluoromethyl)pyrazine-2-carboxamide, which is a common partial structural motif of the compound having an Aβ production inhibitory action or a BACE1 inhibitory action, can be industrially advantageously produced by decarboxylating 5-[carboxy(difluoro)methyl]pyrazine-2-carboxylic acid, which is obtainable from 5-chloropyrazine-2-carboxylate.