The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2016
Filed:
Mar. 14, 2014
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Martin G. Pomper, Baltimore, MD (US);
Ronnie Charles Mease, Fairfax, VA (US);
Ying Chen, Timmonium, MD (US);
Assignee:
THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); C07C 275/18 (2006.01); A61K 51/04 (2006.01); A61K 9/127 (2006.01); C07C 275/16 (2006.01); C07D 213/61 (2006.01); C07D 213/74 (2006.01); C07D 213/82 (2006.01); C07F 7/22 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0402 (2013.01); A61K 9/127 (2013.01); A61K 51/0455 (2013.01); C07C 275/16 (2013.01); C07C 275/18 (2013.01); C07D 213/61 (2013.01); C07D 213/74 (2013.01); C07D 213/82 (2013.01); C07F 7/2212 (2013.01); C07B 2200/05 (2013.01);
Abstract
Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.