The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2016
Filed:
Mar. 12, 2015
Applicant:
Sillajen Biotherapeutics, Inc., San Francisco, CA (US);
Inventor:
David Kirn, San Francisco, CA (US);
Assignee:
SillaJen Biotherapeutics, Inc., San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 9/00 (2006.01); A61K 38/19 (2006.01); A61K 45/06 (2006.01); A61K 35/768 (2015.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); A61K 9/0019 (2013.01); A61K 35/768 (2013.01); A61K 38/193 (2013.01); A61K 45/06 (2013.01); A61K 48/0075 (2013.01); A61K 48/00 (2013.01); C12N 2710/24132 (2013.01);
Abstract
Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include administering the vaccinia virus at increased viral concentrations. Further aspects of the invention include methods for inducing oncolysis or collapse of tumor vasculature in a subject having a tumor comprising administering to a subject at least 1×10infectious viral particles of a TK-deficient, GM-CSF-expressing, replication-competent vaccinia virus vector sufficient to induce oncolysis of cells in the tumor.