The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2016
Filed:
Mar. 21, 2013
Applicant:
Hepacore Ltd., Ness Ziona, IL;
Inventors:
Avner Yayon, Moshav Sitria, IL;
Eran Rom, Rehovot, IL;
Roy Sirkis, Ness Ziona, IL;
Dalit Strauss-Ayali, Sde Warburg, IL;
Assignee:
HEPACORE LTD., Ness Ziona, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); C07K 14/50 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1825 (2013.01); A61K 45/06 (2013.01); C07K 14/50 (2013.01);
Abstract
The present invention relates to fibroblast growth factor 18 (FGF-18) variants having various truncations beyond the signal peptide domain of the N-terminus, which activate FGFR3 with increased specificity. The invention further relates to polynucleotides encoding the variants, pharmaceutical compositions comprising same and methods for use thereof in treating cartilage and skeletal disorders.