The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2016
Filed:
Nov. 29, 2011
Ross Wentworth Stephens, Stirling Australian Capital Territory, AU;
Christopher Richard Parish, Campbell Australian Capital Territory, AU;
Craig Geoffrey Freeman, New South Wales, AU;
Timothy John Senden, Aranda Australian Capital Territory, AU;
Ross Wentworth Stephens, Stirling Australian Capital Territory, AU;
Christopher Richard Parish, Campbell Australian Capital Territory, AU;
Craig Geoffrey Freeman, New South Wales, AU;
Timothy John Senden, Aranda Australian Capital Territory, AU;
THE AUSTRALIAN NATIONAL UNIVERSITY, Acton, Australian Capital Territory, AU;
Abstract
The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method for the treatment of patients who are suffering from sepsis and employs polyanions to rapidly form complexes with and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the blood circulation of sepsis patients.